We focus on developing the basic science coupled with advanced nanomanufacturing needed to translate the extraordinary properties of two-dimensional (2D) materials, from chalcogenides, nitrides, and oxides to graphene, into real-world applications. To this end, we stand out by offering a transformative set of solid-state chemistries, new physical understanding of additive nanomanufacturing, and applied approaches that allow us to access unprecedented structure-property-function relationships – crucial to developing innovative applications of 2D materials and their assembly into three-dimensional (3D) bulk-nanostructures, including electrochemical capacitors, catalysis, reactors and separation, drug delivery, sensing and highly complexity composites.